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A debate on the neuronal origin of focal seizures

Lookup NU author(s): Professor Andrew Trevelyan



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2023 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy. A critical question regarding how focal seizures start is whether we can identify particular cell classes that drive the pathological process. This was the topic for debate at the recent International Conference for Technology and Analysis of Seizures (ICTALS) meeting (July 2022, Bern, CH) that we summarize here. The debate has been fueled in recent times by the introduction of powerful new ways to manipulate subpopulations of cells in relative isolation, mostly using optogenetics. The motivation for resolving the debate is to identify novel targets for therapeutic interventions through a deeper understanding of the etiology of seizures.

Publication metadata

Author(s): Wenzel M, Huberfeld G, Grayden DB, de Curtis M, Trevelyan AJ

Publication type: Article

Publication status: Published

Journal: Epilepsia

Year: 2023

Volume: 64

Issue: S3

Pages: S37-S48

Online publication date: 15/05/2023

Acceptance date: 12/05/2023

Date deposited: 28/06/2023

ISSN (print): 0013-9580

ISSN (electronic): 1528-1167

Publisher: John Wiley and Sons Inc.


DOI: 10.1111/epi.17650

PubMed id: 37183507


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Funder referenceFunder name
RF2018 12365681