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Lookup NU author(s): Dr Jessica Graham, Dr Harriet Annabella Stanway-Gordon, Professor Mike Waring
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2023 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.DNA-Encoded Libraries (DELs) are becoming widely established as a hit identification strategy for drug discovery campaigns. Their successful application relies on the availability and efficiency of the reactions that can be carried out on DNA. These reactions should proceed with high conversion to the desired product and have a broad substrate scope to synthesise chemically diverse and drug-like DELs. The Sonogashira coupling provides a unique means of coupling an sp-hybridized carbon centre to an aryl halide and methods to achieve this reaction on DNA are highly desirable. We report the application of our micellar technology for on-DNA chemistry to the Sonogashira reaction. This method gives highly efficient conversions for the coupling of (hetero)aromatic and aliphatic alkynes to (hetero)aryl iodides and bromides allowing the preparation of highly diverse DELs.
Author(s): Graham JS, Stanway-Gordon HA, Waring MJ
Publication type: Article
Publication status: Published
Journal: Chemistry - A European Journal
Year: 2023
Volume: 29
Issue: 42
Print publication date: 26/07/2023
Online publication date: 15/05/2023
Acceptance date: 15/05/2023
Date deposited: 03/07/2023
ISSN (print): 0947-6539
ISSN (electronic): 1521-3765
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1002/chem.202300603
DOI: 10.1002/chem.202300603
Data Access Statement: The data that support the findings of this study are available in the supplementary material of this article.
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