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Lookup NU author(s): Dr Olivier GovaereORCiD, Professor Quentin AnsteeORCiD
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© 2023 AGA InstituteBackground and Aims: Nonalcoholic fatty liver disease (NAFLD) is a complex disease, resulting from the interplay between environmental determinants and genetic variations. Single nucleotide polymorphism rs738409 C>G in the PNPLA3 gene is associated with hepatic fibrosis and with higher risk of developing hepatocellular carcinoma. Here, we analyzed a longitudinal cohort of biopsy-proven NAFLD subjects with the aim to identify individuals in whom genetics may have a stronger impact on disease progression. Methods: We retrospectively analyzed 756 consecutive, prospectively enrolled biopsy-proven NAFLD subjects from Italy, United Kingdom, and Spain who were followed for a median of 84 months (interquartile range, 65–109 months). We stratified the study cohort according to sex, body mass index (BMI)
Author(s): Rosso C, Caviglia GP, Birolo G, Armandi A, Pennisi G, Pelusi S, Younes R, Liguori A, Perez-Diaz-del-Campo N, Nicolosi A, Govaere O, Castelnuovo G, Olivero A, Abate ML, Ribaldone DG, Fariselli P, Valenti L, Miele L, Petta S, Romero-Gomez M, Anstee QM, Bugianesi E
Publication type: Article
Publication status: Published
Journal: Clinical Gastroenterology and Hepatology
Year: 2023
Volume: 21
Issue: 13
Print publication date: 01/12/2023
Online publication date: 04/05/2023
Acceptance date: 02/04/2023
ISSN (print): 1542-3565
ISSN (electronic): 1542-7714
Publisher: Elsevier
URL: https://doi.org/10.1016/j.cgh.2023.04.024
DOI: 10.1016/j.cgh.2023.04.024
PubMed id: 37149016
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