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Sleep disorders in Lewy body dementia: Mechanisms, clinical relevance, and unanswered questions

Lookup NU author(s): Dr Leigh TownsendORCiD, Dr Kirstie Anderson, Emeritus Professor Ian McKeith, Professor John-Paul TaylorORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. In Lewy body dementia (LBD), disturbances of sleep and/or arousal including insomnia, excessive daytime sleepiness, rapid eye movement (REM) sleep behavior disorder, obstructive sleep apnea, and restless leg syndrome are common. These disorders can each exert a significant negative impact on both patient and caregiver quality of life; however, their etiology is poorly understood. Little guidance is available for assessing and managing sleep disorders in LBD, and they remain under-diagnosed and under-treated. This review aims to (1) describe the specific sleep disorders which occur in LBD, considering their putative or potential mechanisms; (2) describe the history and diagnostic process for these disorders in LBD; and (3) summarize current evidence for their management in LBD and consider some of the ongoing and unanswered questions in this field and future research directions.

Publication metadata

Author(s): Townsend LTJ, Anderson KN, Boeve BF, McKeith I, Taylor J-P

Publication type: Review

Publication status: Published

Journal: Alzheimer's and Dementia

Year: 2023

Volume: 19

Issue: 11

Pages: 5264-5283

Print publication date: 01/11/2023

Online publication date: 01/07/2023

Acceptance date: 26/05/2023

ISSN (print): 1552-5260

ISSN (electronic): 1552-5279

Publisher: John Wiley and Sons Inc


DOI: 10.1002/alz.13350

PubMed id: 37392199