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Lookup NU author(s): Dr Richard Quinton
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
© The Author(s) 2023.Background: Inter-assay variation between different immunoassays and different mass spectrometry methods hampers the biochemical confirmation of male hypogonadism. Furthermore, some laboratories utilis eassay manufacturer reference ranges that do not necessarily mirror assay performance characteristics, with the lower limit of normality ranging from 4.9 nmol/L to 11 nmol/L. The quality of the normative data underlying commercial immunoassay reference ranges is uncertain. Design: A working group reviewed published evidence and agreed upon standardised reporting guidance to augment total testosterone reports. Results: Evidence-based guidance on appropriate blood sampling, clinical action limits, and other major factors likely to affect the interpretation of results are provided. Conclusions: This article aims to improve the quality of the interpretation of testosterone results by non-specialist clinicians. It also discusses approaches for assay harmonisation which have been successful in some but not all healthcare systems.
Author(s): Jayasena CN, de Silva NL, O'Reilly MW, MacKenzie F, Marrington R, Jones H, Livingston M, Downie P, Hackett G, Ramachandran S, Tomlinson J, David J, Boot C, Patel M, Tarling J, Wu F, Quinton R
Publication type: Article
Publication status: Published
Journal: Annals of Clinical Biochemistry
Year: 2023
Volume: 60
Issue: 4
Pages: 223-227
Print publication date: 01/07/2023
Online publication date: 30/06/2023
Acceptance date: 12/05/2023
Date deposited: 01/08/2023
ISSN (print): 0004-5632
ISSN (electronic): 1758-1001
Publisher: SAGE Publications Ltd
URL: https://doi.org/10.1177/00045632231179022
DOI: 10.1177/00045632231179022
PubMed id: 37391940
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