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Complex interactions of cellular players in chronic Graft-versus-Host Disease

Lookup NU author(s): Kimberly Schell, Steve Bolton, Dr Rachel CrosslandORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Copyright © 2023 Gail, Schell, Łacina, Strobl, Bolton, Steinbakk Ulriksen, Bogunia-Kubik, Greinix, Crossland, Inngjerdingen and Stary.Chronic Graft-versus-Host Disease is a life-threatening inflammatory condition that affects many patients after allogeneic hematopoietic stem cell transplantation. Although we have made substantial progress in understanding disease pathogenesis and the role of specific immune cell subsets, treatment options are still limited. To date, we lack a global understanding of the interplay between the different cellular players involved, in the affected tissues and at different stages of disease development and progression. In this review we summarize our current knowledge on pathogenic and protective mechanisms elicited by the major involved immune subsets, being T cells, B cells, NK cells and antigen presenting cells, as well as the microbiome, with a special focus on intercellular communication of these cell types via extracellular vesicles as up-and-coming fields in chronic Graft-versus-Host Disease research. Lastly, we discuss the importance of understanding systemic and local aberrant cell communication during disease for defining better biomarkers and therapeutic targets, eventually enabling the design of personalized treatment schemes.

Publication metadata

Author(s): Gail LM, Schell KJ, Lacina P, Strobl J, Bolton SJ, Steinbakk Ulriksen E, Bogunia-Kubik K, Greinix H, Crossland RE, Inngjerdingen M, Stary G

Publication type: Review

Publication status: Published

Journal: Frontiers in Immunology

Year: 2023

Volume: 14

Online publication date: 26/07/2023

Acceptance date: 07/06/2023

ISSN (electronic): 1664-3224

Publisher: Frontiers Media SA


DOI: 10.3389/fimmu.2023.1199422

PubMed id: 37435079