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Tolerogenic dendritic cell reporting: Has a minimum information model made a difference?

Lookup NU author(s): Ayesha Sahar, Ioana Nicorescu, Professor Catharien Hilkens, Dr Phillip Lord

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

Copyright 2023 Sahar et al. Minimum information models are reporting frameworks that describe the essential information that needs to be provided in a publication, so that the work can be repeated or compared to other work. In 2016, Minimum Information about Tolerogenic Antigen-Presenting cells (MITAP) was created to standardize the reporting on tolerogenic antigen-presenting cells, including tolerogenic dendritic cells (tolDCs). tolDCs is a generic term for dendritic cells that have the ability to (re-)establish immune tolerance; they have been developed as a cell therapy for autoimmune diseases or for the prevention of transplant rejection. Because protocols to generate these therapeutic cells vary widely, MITAP was deemed to be a pivotal reporting tool by and for the tolDC community. In this paper, we explored the impact that MITAP has had on the tolDC field. We did this by examining a subset of the available literature on tolDCs. Our analysis shows that MITAP is used in only the minority of relevant papers (14%), but where it is used the amount of metadata available is slightly increased over where it is not. From this, we conclude that MITAP has been a partial success, but that much more needs to be done if standardized reporting is to become common within the discipline.


Publication metadata

Author(s): Sahar A, Nicorescu I, Barran G, Paterson M, Hilkens CMU, Lord P

Publication type: Article

Publication status: Published

Journal: PeerJ

Year: 2023

Volume: 11

Online publication date: 31/05/2023

Acceptance date: 13/04/2023

Date deposited: 27/07/2023

ISSN (electronic): 2167-8359

Publisher: PeerJ Inc.

URL: https://doi.org/10.7717/peerj.15352

DOI: 10.7717/peerj.15352


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Funding

Funder referenceFunder name
BB/S507039/1
860003
BBSRC/GSK Case studentship
European Union Horizon 2020

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