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Lookup NU author(s): Dr Sviatlana Zhyzhneuskaya,
Emeritus Professor Roy Taylor
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© 2019, Springer Nature Switzerland AG. This chapter separately describes the pathophysiology of type 2 diabetes and that of obesity, and identifies the relationship between these states. The important concept of long-term reversibility of type 2 diabetes is discussed along with the beta-cell dedifferentiation, which explains the insulin secretory defect. Obesity brings about distinct pathophysiological changes as a consequence of individuals’ pattern of food intake and levels of activity. The practical issue of clinical management is considered with particular reference to the weight management goals for type 2 diabetes. Following therapeutic weight loss in both conditions, long-term avoidance of weight regain is vital and is optimally achieved by a combination of ongoing food energy restriction and daily physical activity.
Author(s): Zhyzhneuskaya S, Taylor R
Publication type: Book Chapter
Publication status: Published
Book Title: Obesity: Pathogenesis, Diagnosis, and Treatment
Print publication date: 23/01/2019
Online publication date: 08/01/2019
Acceptance date: 02/04/2018
Series Title: Endocrinology
Place Published: Cham
PubMed id: 31108553
Library holdings: Search Newcastle University Library for this item