Toggle Main Menu Toggle Search

Open Access padlockePrints

Insulin biobetters and biosimilars in clinical practice

Lookup NU author(s): Emeritus Professor Philip Home

Downloads


Licence

This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© The Author(s) 2023.Insulin injections have never been an entirely satisfactory therapy, and as a result a continuing ‘biobetter’ technological cascade has driven changes in purity and manufacture, in structure and excipients, and in administration devices. The resulting deck of insulin preparations has to be matched by health-care teams and users with individual need. This latter is itself a complex ranging from ambulatory care in type 1 and type 2 diabetes, the topic generally addressed by guidelines and funding advice, to in-patient care and the newly diagnosed, plus secondary diabetes with very different effects on insulin need, through to co-morbidities and medications interfering with glucose metabolism. In this article the match of different clinical scenarios to the available insulins is discussed in the context of available evidence, quality guidelines, and diabetes best practice. Additionally the role of biosimilars of the insulin analogues is addressed, their limited but useful price advantage, and the management consequences of substitution for the originator product.


Publication metadata

Author(s): Home P

Publication type: Review

Publication status: Published

Journal: Journal of the Royal College of Physicians of Edinburgh

Year: 2023

Volume: 53

Issue: 2

Pages: 147-155

Print publication date: 01/06/2023

Online publication date: 18/05/2023

Acceptance date: 02/04/2023

ISSN (print): 1478-2715

ISSN (electronic): 2042-8189

Publisher: SAGE Publications Inc.

URL: https://doi.org/10.1177/14782715231173770

DOI: 10.1177/14782715231173770

PubMed id: 37198930


Share