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Lookup NU author(s): Manuel Banzhaf
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© 2022 Elsevier B.V. Atopic dermatitis (AD) is a common andcomplex disorder caused by many inherently intractable factors. One of the symptoms is an increased amount of Staphylococcus aureus on the skin surface. These bacteria trigger, accelerate, and exacerbate AD. In order to reduce inflammation, we designed antimicrobial patches, which inhibit bacterial growth. Using electrospinning, we produced polyimide (PI) nanofibers collected in the form of porous membranes. These PI membranes were modified with sodium hypochlorite (NaOCl). The active chlorine content was confirmed with scanning electron microscopy (SEM) with secondary electrons (SE) mode, backscattered electrons (BSE) mode, and energy-dispersive X-ray (EDX) spectroscopy, with Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). Moreover, we evaluated the wettability and zeta potential of the patches. Finally, we performed an antimicrobial efficacy assay against the Gram-positive model organism S. aureus and the Gram-negative model, Escherichia coli. We observed that the chlorinated PI patches demonstrate effective bacterial killing, making them excellent material for antimicrobial skin patches applications.
Author(s): Sroczyk EA, Bryant JA, de Cogan F, Knapczyk-Korczak J, Marzec MM, Szewczyk PK, Banzhaf M, Stachewicz U
Publication type: Article
Publication status: Published
Journal: Applied Surface Science
Year: 2022
Volume: 592
Print publication date: 01/08/2022
Online publication date: 09/04/2022
Acceptance date: 02/04/2022
Date deposited: 23/08/2023
ISSN (print): 0169-4332
ISSN (electronic): 1873-5584
Publisher: Elsevier BV
URL: https://doi.org/10.1016/j.apsusc.2022.153302
DOI: 10.1016/j.apsusc.2022.153302
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