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Lookup NU author(s): Manuel Banzhaf
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.Bacteria must maintain the ability to modify and repair the peptidoglycan layer without jeopardising its essential functions in cell shape, cellular integrity and intermolecular interactions. A range of new experimental techniques is bringing an advanced understanding of how bacteria regulate and achieve peptidoglycan synthesis, particularly in respect of the central role played by complexes of Sporulation, Elongation or Division (SEDs) and class B penicillin-binding proteins required for cell division, growth and shape. In this review we highlight relationships implicated by a bioinformatic approach between the outer membrane, cytoskeletal components, periplasmic control proteins, and cell elongation/division proteins to provide further perspective on the interactions of these cell division, growth and shape complexes. We detail the network of protein interactions that assist in the formation of peptidoglycan and highlight the increasingly dynamic and connected set of protein machinery and macrostructures that assist in creating the cell envelope layers in Gram-negative bacteria.
Author(s): Graham CLB, Newman H, Gillett FN, Smart K, Briggs N, Banzhaf M, Roper DI
Publication type: Review
Publication status: Published
Journal: International Journal of Molecular Sciences
Year: 2021
Volume: 22
Issue: 23
Print publication date: 01/12/2021
Online publication date: 27/11/2021
Acceptance date: 03/11/2021
ISSN (print): 1661-6596
ISSN (electronic): 1422-0067
Publisher: MDPI
URL: https://doi.org/10.3390/ijms222312831
DOI: 10.3390/ijms222312831
PubMed id: 34884635
Data Access Statement: The interaction network of proteins, with DOI citations at each interaction pair can be found in the paper’s supplementary data file. The predicted gene network used for Figure 4 is available at STRING’s website using the permalink: https://version-11-5.string-db.org/cgi/network?taskId=bIzLkBRoqjLb&sessionId=bBi0rwtoih3p
