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Standardizing Scoring Conventions for Crohn's Disease Endoscopy: An International RAND/UCLA Appropriateness Study

Lookup NU author(s): Dr Matthew Rutter

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Abstract

© 2023 AGA InstituteBackground and Aims: Endoscopic assessment of disease activity is integral for evaluating treatment response in patients with Crohn's disease (CD). We aimed to define appropriate items for evaluating endoscopic activity and conventions for consistent endoscopic scoring rules in CD. Methods: A 2-round modified RAND/University of California at Los Angeles Appropriateness Method study was conducted. A panel of 15 gastroenterologists used a 9-point Likert scale to rate the appropriateness of statements pertaining to the Simple Endoscopic Score for CD, Crohn's Disease Endoscopic Index of Severity, and additional items relevant to endoscopy scoring in CD. Each statement was voted as appropriate, uncertain, or inappropriate based on the median panel rating and presence of disagreement. Results: Panelists voted that it is appropriate for all ulcers to contribute to endoscopic scoring in CD, including aphthous ulcers, ulcerations at a surgical anastomosis, and anal canal ulcers (scored in the rectum). Endoscopic healing should reflect an absence of ulcers. Narrowing should be defined as a clear decrease in luminal diameter; stenosis should be defined by an impassable narrowing, and if occurring at the junction of 2 segments, scored in the distal segment. Scarring and inflammatory polyps were considered inappropriate for including in the affected area score. The optimal method for defining ulcer depth remains uncertain. Conclusions: We outlined scoring conventions for the Simple Endoscopic Score for CD and Crohn's Disease Endoscopic Index of Severity, noting that both scores have limitations. Therefore, we identified priorities for future research and steps for developing and validating a more representative endoscopic index in CD.

Publication metadata

Author(s): Khanna R, Ma C, Hogan M, Zou G, Bessissow T, Bressler B, Colombel J-F, Danese S, Daperno M, East JE, Hookey L, Loftus EV, McDonald JWD, Panaccione R, Peyrin-Biroulet L, Rutter M, Sands BE, Vermeire S, Remillard J, McFarlane SC, Sandborn WJ, D'Haens GR, Feagan BG, Jairath V

Publication type: Article

Publication status: Published

Journal: Clinical Gastroenterology and Hepatology

Year: 2023

Volume: 21

Issue: 11

Pages: P2938-2950.E6

Online publication date: 10/06/2023

Acceptance date: 02/04/2023

ISSN (print): 1542-3565

ISSN (electronic): 1542-7714

Publisher: W.B. Saunders

URL: https://doi.org/10.1016/j.cgh.2023.05.029

DOI: 10.1016/j.cgh.2023.05.029

PubMed id: 37308036

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