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Lookup NU author(s): Nick Chilvers, Professor John Dark
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© 2023. Heart transplantation is the definitive treatment for selected patients with end-stage heart failure refractory to medical, interventional and surgical treatment. However, due to a limited number of donor organs, most patients wait a long time for heart transplantation and a significant proportion die or become unsuitable for transplantation while waiting. Although post-transplant survival outcomes continue improving, a fifth of recipients die within 1 year after transplantation. In addition, recipients face constant threats from infection, rejection, malignancy and chronic allograft vasculopathy. Therefore, it is imperative to increase donor heart utilization to reduce waiting list mortality, maintain allograft quality during transportation and optimize post-transplant care to improve outcomes. This review summarizes the process of heart transplantation from recipient and donor selection and matching to post-transplant management with a focus on the surgical aspects, and highlights recent advancements, including the donation after circulatory death programme, mechanical circulatory support, and ex vivo heart perfusion.
Author(s): Chilvers N, Dark JH
Publication type: Review
Publication status: Published
Journal: Surgery
Year: 2023
Pages: Epub ahead of print
Online publication date: 28/07/2023
Acceptance date: 02/04/2018
ISSN (print): 0263-9319
ISSN (electronic): 1878-1764
Publisher: Elsevier Ltd
URL: https://doi.org/10.1016/j.mpsur.2023.06.003
DOI: 10.1016/j.mpsur.2023.06.003
