Toggle Main Menu Toggle Search

Open Access padlockePrints

Outcomes of N-butyl-2-Cyanoacrylate Tissue Adhesive Application in Corneal Perforation Disorders: Consecutive Case Series

Lookup NU author(s): Professor Francisco FigueiredoORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2023, The Author(s). Introduction: The purpose of this study was to report the success and long-term outcomes of cyanoacrylate tissue adhesive (CTA) application in the management of corneal perforation disorders. Methods: This retrospective case series describes the profile and outcomes of eyes that underwent CTA for corneal perforation over an 11-year period from January 2009 until January 2020 at a tertiary eye centre in the United Kingdom. Results: In total, 25 eyes underwent CTA application during the study period. Non-traumatic sterile corneal melt was responsible in more than half of the cases (56.0%; n = 14) followed by infection (32.0%; n = 8) and trauma (12.0%; n = 3). Median size of perforation was 2.0 mm (interquartile range, IQR 1.0–3.0). The most common anatomical location of corneal perforation was central (56.0%; n = 14). Ocular surface disease was seen in almost all eyes except two (92.0%; n = 23) with dry eye disease being the most common (48.0%; n = 12). Amongst 23 eyes that completed follow-up (median 27 months; IQR 9.5–46.5), single CTA application was successful in achieving intact globe in 13 (56.5%) eyes and repeat gluing sealed total of 20 (86.9%) eyes. Survival analysis showed cumulative success of 71.0% and 51.2% at 90 and 250 days, respectively. The CTA was retained in the eyes for median of 94.0 days (IQR 30.0–140.5). A total of five patients developed adverse events, including endophthalmitis (n = 2), following CTA application. Conclusions: CTA was highly effective in sealing corneal perforations in acute setting and showed moderate long-term success. However, multiple applications are often required.

Publication metadata

Author(s): Sadiq SN, Cartes C, Sarfraz MN, Figueiredo FC

Publication type: Article

Publication status: Published

Journal: Ophthalmology and Therapy

Year: 2023

Volume: 12

Pages: 3403-3413

Online publication date: 17/08/2023

Acceptance date: 27/07/2023

Date deposited: 15/09/2023

ISSN (print): 2193-8245

ISSN (electronic): 2193-6528

Publisher: Springer


DOI: 10.1007/s40123-023-00785-y


Altmetrics provided by Altmetric