Toggle Main Menu Toggle Search

Open Access padlockePrints

Spatial organisation of the mesoscale connectome: A feature influencing synchrony and metastability of network dynamics

Lookup NU author(s): Dr Michael Mackay, Professor Marcus Kaiser

Downloads


Licence

This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

Copyright: © 2023 Mackay et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Significant research has investigated synchronisation in brain networks, but the bulk of this work has explored the contribution of brain networks at the macroscale. Here we explore the effects of changing network topology on functional dynamics in spatially constrained random networks representing mesoscale neocortex. We use the Kuramoto model to simulate network dynamics and explore synchronisation and critical dynamics of the system as a function of topology in randomly generated networks with a distance-related wiring probability and no preferential attachment term. We show networks which predominantly make short-distance connections smooth out the critical coupling point and show much greater metastability, resulting in a wider range of coupling strengths demonstrating critical dynamics and metastability. We show the emergence of cluster synchronisation in these geometrically-constrained networks with functional organisation occurring along structural connections that minimise the participation coefficient of the cluster. We show that these cohorts of internally synchronised nodes also behave en masse as weakly coupled nodes and show intra-cluster desynchronisation and resynchronisation events related to inter-cluster interaction. While cluster synchronisation appears crucial to healthy brain function, it may also be pathological if it leads to unbreakable local synchronisation which may happen at extreme topologies, with implications for epilepsy research, wider brain function and other domains such as social networks.


Publication metadata

Author(s): Mackay M, Huo S, Kaiser M

Publication type: Article

Publication status: Published

Journal: PLoS Computational Biology

Year: 2023

Volume: 19

Issue: 8

Online publication date: 08/08/2023

Acceptance date: 12/07/2023

Date deposited: 05/09/2023

ISSN (print): 1553-734X

ISSN (electronic): 1553-7358

Publisher: Public Library of Science

URL: https://doi.org/10.1371/journal.pcbi.1011349

DOI: 10.1371/journal.pcbi.1011349

Data Access Statement: The source code used to produce the results and analyses presented in this manuscript are available as supplementary information: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011349#sec012 (zip-file).

PubMed id: 37552650


Altmetrics

Altmetrics provided by Altmetric


Funding

Funder referenceFunder name
102037
EPSRC
Guangci Professorship Program of Ruijin Hospital
MR/T004347/1Medical Research Council (MRC)
NS/A000026/1
Wellcome Trust

Share