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Lookup NU author(s): Professor Matthew Prina
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Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. BACKGROUND: Positron emission tomography (PET) scans for amyloid-β can aid in the early and accurate detection of Alzheimer disease. The results of amyloid PET scans could help people with cognitive impairment and caregivers better understand their diagnosis; however, there are concerns that they could also cause psychological harm. METHODS: A systematic review of psychosocial and behavioral quantitative outcomes following the disclosure of an amyloid PET scan for persons living with cognitive impairment (subjective cognitive decline, mild cognitive impairment, Alzheimer's Disease, and other dementias) and caregivers. FINDINGS: Ten papers were identified from 7 studies. There was little evidence of an association between disclosure and depression. However, persons with mild cognitive impairment and their caregivers with elevated levels of amyloid had an increased risk of distress or anxiety compared with those without elevated amyloid. Participants correctly recalled the scan results; however, it is unclear whether this led to an increased understanding of their diagnosis. We did not identify any studies measuring behavioral outcomes. CONCLUSIONS: We found mixed evidence on the relationship between amyloid scans and psychosocial and behavioral outcomes in people with cognitive impairment and caregivers. These findings highlight the need for more methodologically rigorous research on this topic.
Author(s): Couch E, Ashford MT, Zhang W, Prina M
Publication type: Article
Publication status: Published
Journal: Alzheimer Disease and Associated Disorders
Year: 2023
Volume: 37
Issue: 3
Pages: 246-258
Print publication date: 01/07/2023
Acceptance date: 02/04/2018
ISSN (print): 0893-0341
ISSN (electronic): 1546-4156
Publisher: Lippincott Williams & Wilkins
URL: https://doi.org/10.1097/WAD.0000000000000569
DOI: 10.1097/WAD.0000000000000569
PubMed id: 37561950
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