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Lookup NU author(s): Dr Kheng-Lim GohORCiD
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The connective tissues such as tendons contain an extracellular matrix (ECM) comprising collagen fibrils scattered within the ground substance. These fibrils are instrumental in lending mechanical stability to tissues. Unfortunately, our understanding of how collagen fibrils reinforce the ECM remains limited, with no direct experimental evidence substantiating current theories. Earlier theoretical studies on collagen fibril reinforcement in the ECM have relied predominantly on the assumption of uniform cylindrical fibers, which is inadequate for modelling collagen fibrils, which possessed tapered ends. Recently, Topçu and colleagues published a paper in the International Journal of Solids and Structures, presenting a generalized shear-lag theory for the transfer of elastic stress between the matrix and fibers with tapered ends. This paper is a positive step towards comprehending the mechanics of the ECM and makes a valuable contribution to formulating a complete theory of collagen fibril reinforcement in the ECM.
Author(s): Goh KL, Topcu M, Madabhushi GSP, Staat M
Editor(s): Fatima Raquel Azevedo Maia; J. Miguel Oliveira; Rui L. Reis
Publication type: Book Chapter
Publication status: Published
Book Title: Handbook of the Extracellular Matrix: Biologically-Derived Materials
Year: 2023
Online publication date: 19/07/2023
Acceptance date: 01/07/2023
Publisher: Springer
Place Published: Cham, Switzerland
URL: https://doi.org/10.1007/978-3-030-92090-6_6-1
DOI: 10.1007/978-3-030-92090-6_6-1
Notes: In collaboration with Cambridge University Researchers, Mr Topcu M, and Professor Madabhushi GSP, and Professor Staat M (Aachen University)
Library holdings: Search Newcastle University Library for this item
ISBN: 9783030920906
