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1,4-Dimethoxynaphthalene-2-methyl (‘DIMON’), an oxidatively labile protecting group for synthesis of polyunsaturated lipids

Lookup NU author(s): Dr Jay Tromans, Dr Bian Zhang, Emeritus Professor Bernard Golding



This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


© 2023 The Royal Society of Chemistry. A new benzyl-type protecting group (1,4-dimethoxynaphthalene-2-methyl, ‘DIMON’) for hydroxyl functions can be selectively removed under oxidative conditions without damaging polyunsaturated fatty acyl groups. Its application is shown by the first synthesis of an ether (plasmanyl) phospholipid containing the docosa-(4Z,7Z,10Z,13Z,16Z,19Z)-hexaenoyl group.

Publication metadata

Author(s): Tromans J, Zhang B, Golding BT

Publication type: Article

Publication status: Published

Journal: Chemical Communications

Year: 2023

Volume: 59

Pages: 13333-13335

Online publication date: 23/10/2023

Acceptance date: 16/10/2023

Date deposited: 08/11/2023

ISSN (print): 1359-7345

ISSN (electronic): 1364-548X

Publisher: Royal Society of Chemistry


DOI: 10.1039/d3cc04292h

PubMed id: 37867450


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Funder referenceFunder name
BiBerChem Research
European Research and Development Fund (ERDF)