Browse by author
Lookup NU author(s): Dr Karoline LeibergORCiD, Dr Beth LittleORCiD, Professor Peter TaylorORCiD, Professor Yujiang WangORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Neuroimaging can capture brain restructuring after anterior temporal lobe resection (ATLR), a surgical procedure to treat drug-resistant temporal lobe epilepsy (TLE). Here, we examine the effects of this surgery on brain morphology measured in recently-proposed independent variables.We studied 101 individuals with TLE (55 left, 46 right onset) who underwent ATLR. For each individual we considered one pre-surgical MRI and one follow-up MRI 2–13 months after surgery. We used a surface-based method to locally compute traditional morphological variables, and the independent measures K, I, and S, where K measures white matter tension, I captures isometric scaling, and S contains the remaining information about cortical shape. A normative model trained on data from 924 healthy controls was used to debias the data and account for healthy ageing effects occurring during scans. A SurfStat random field theory clustering approach assessed changes across the cortex caused by ATLR.Compared to preoperative data, surgery had marked effects on all morphological measures. Ipsilateral effects were located in the orbitofrontal and inferior frontal gyri, the pre- and postcentral gyri and supramarginal gyrus, and the lateral occipital gyrus and lingual cortex. Contralateral effects were in the lateral occipital gyrus, and inferior frontal gyrus and frontal pole.The restructuring following ATLR is reflected in widespread morphological changes, mainly in regions near the resection, but also remotely in regions that are structurally connected to the anterior temporal lobe. The causes could include mechanical effects, Wallerian degeneration, or compensatory plasticity. The study of independent measures revealed additional effects compared to traditional measures.
Author(s): Leiberg K, de Tisi J, Duncan JS, Little B, Taylor PN, Vos SB, Winston GP, Mota B, Wang Y
Publication type: Article
Publication status: Published
Journal: Cortex
Year: 2023
Volume: 166
Pages: 233-242
Print publication date: 01/09/2023
Online publication date: 08/06/2023
Acceptance date: 16/04/2023
Date deposited: 08/11/2023
ISSN (print): 0010-9452
ISSN (electronic): 1973-8102
Publisher: Elsevier BV
URL: https://doi.org/10.1016/j.cortex.2023.04.018
DOI: 10.1016/j.cortex.2023.04.018
Data Access Statement: The NKI data set is available at http://fcon_1000.projects.nitrc.org/indi/enhanced/. Patient data will be shared as part of a larger public data repository planned for 2023/2024. To discuss data access ahead of the release, please contact one of the corresponding authors. De-identified imaging data for each individual summarised as their morphological information can be found on zenodo (https://doi.org/10.5281/zenodo.7957831). The analysis code can be found on github (https://github.com/cnnp-lab/2023Leiberg_ATLRmorphology).
Notes: Temporal lobe epilepsyCortical morphologyStructural MRIEpilepsy surgery
Altmetrics provided by Altmetric
