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Lookup NU author(s): Kathryn BushORCiD, Jennifer Rankin, Professor Sheena Ramsay
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ.INTRODUCTION: Evidence from longitudinal studies on the influence of neighborhood socioeconomic deprivation in older age on the development of type 2 diabetes mellitus (T2DM) is limited. This study investigates the prospective associations of neighborhood-level deprivation and individual socioeconomic position (SEP) with T2DM incidence in older age. RESEARCH DESIGN AND METHODS: The British Regional Heart Study studied 4252 men aged 60-79 years in 1998-2000. Neighborhood-level deprivation was based on the Index of Multiple Deprivation quintiles for participants' 1998-2000 residential postcode. Individual SEP was defined as social class based on longest-held occupation. A cumulative score of individual socioeconomic factors was derived. Incident T2DM cases were ascertained from primary care records; prevalent cases were excluded. Cox proportional hazard models were used to examine the associations. RESULTS: Among 3706 men, 368 incident cases of T2DM were observed over 18 years. The age-adjusted T2DM risk increased from the least deprived quintile to the most deprived: HR per quintile increase 1.14 (95% CI 1.06 to 1.23) (p=0.0005). The age-adjusted T2DM HR in social class V (lowest) versus social class I (highest) was 2.45 (95% CI 1.36 to 4.42) (p=0.001). Both associations attenuated but remained significant on adjustment for other deprivation measures, becoming non-significant on adjustment for body mass index and T2DM family history. T2DM risk increased with cumulative individual adverse socioeconomic factors: HR per point increase 1.14 (95% CI 1.05 to 1.24). CONCLUSIONS: Inequalities in T2DM risk persist in later life, both in relation to neighborhood-level and individual-level socioeconomic factors. Underlying modifiable risk factors continue to need to be addressed in deprived older age populations to reduce disease burden.
Author(s): Bush KJ, Papacosta AO, Lennon LT, Rankin J, Whincup PH, Wannamethee SG, Ramsay SE
Publication type: Article
Publication status: Published
Journal: BMJ open diabetes research & care
Year: 2023
Volume: 11
Issue: 5
Online publication date: 31/10/2023
Acceptance date: 06/10/2023
Date deposited: 09/01/2024
ISSN (electronic): 2052-4897
Publisher: BMJ Publishing Group
URL: http://dx.doi.org/10.1136/bmjdrc-2023-003559
DOI: 10.1136/bmjdrc-2023-003559
Data Access Statement: Data are available from the British Regional Heart Study subject to request approval: https://www.ucl.ac.uk/epidemiology-health-care/research/primary-care-and-population-health/research/ageing/british-regional-heart-study-brhs/brhs-2.
PubMed id: 37907278
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