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Lookup NU author(s): Professor Christopher StewartORCiD, Dr Simon Bridge, Dr Claire Granger, Professor Janet Berrington, Professor Nicholas EmbletonORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
© 2023 The AuthorsPhages and lipids in human milk (HM) may benefit preterm infant health by preventing gastrointestinal pathobiont overgrowth and microbiome modulation. Lipid association may promote vertical transmission of phages to the infant. Despite this, interrelationships between lipids and phages are poorly characterized in preterm HM. Shotgun metagenomics and untargeted lipidomics of phage and lipid profiles from 99 preterm HM samples reveals that phages are abundant and prevalent from the first week and throughout the first 100 days of lactation. Phage-host richness of preterm HM increases longitudinally. Core phage communities characterized by Staphylococcus- and Propionibacterium-infecting phages are significantly correlated with long-chain fatty acid abundances over lactational age. We report here a phage-lipid interaction in preterm HM, highlighting the potential importance of phage carriage in preterm HM. These results reveal possible strategies for phage carriage in HM and their importance in early-life microbiota development.
Author(s): Yew WC, Young GR, Nelson A, Cheung W, Stewart CJ, Bridge SH, Granger C, Berrington JE, Embleton ND, Smith DL
Publication type: Article
Publication status: Published
Journal: Cell Reports
Year: 2023
Volume: 42
Issue: 11
Print publication date: 28/11/2023
Online publication date: 16/11/2023
Acceptance date: 18/10/2023
Date deposited: 27/11/2023
ISSN (electronic): 2211-1247
Publisher: Elsevier B.V.
URL: https://doi.org/10.1016/j.celrep.2023.113373
DOI: 10.1016/j.celrep.2023.113373
Data Access Statement: All original code has been deposited at ENA (PRJEB58774) and is publicly available as of the date of publication. Lipidomic data are available upon request. DOIs are listed in the key resources table. This publication did not generate any original code. Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.
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