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Lookup NU author(s): Dr Valeria Di Leo, Dr Tiago Gomes Bernardino Gomes, Dr Amy VincentORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2023 The Author(s). Mitochondrial dysfunction in skeletal muscle fibres occurs with both healthy aging and a range of neuromuscular diseases. The impact of mitochondrial dysfunction in skeletal muscle and the way muscle fibres adapt to this dysfunction is important to understand disease mechanisms and to develop therapeutic interventions. Furthermore, interactions between mitochondrial dysfunction and skeletal muscle biology, in mitochondrial myopathy, likely have important implications for normal muscle function and physiology. In this review, we will try to give an overview of what is known to date about these interactions including metabolic remodelling, mitochondrial morphology, mitochondrial turnover, cellular processes and muscle cell structure and function. Each of these topics is at a different stage of understanding, with some being well researched and understood, and others in their infancy. Furthermore, some of what we know comes from disease models. Whilst some findings are confirmed in humans, where this is not yet the case, we must be cautious in interpreting findings in the context of human muscle and disease. Here, our goal is to discuss what is known, highlight what is unknown and give a perspective on the future direction of research in this area.
Author(s): Di Leo V, Bernardino Gomes TM, Vincent AE
Publication type: Review
Publication status: Published
Journal: Biochemical Journal
Year: 2023
Volume: 480
Issue: 21
Pages: 1767-1789
Online publication date: 15/11/2023
Acceptance date: 26/10/2023
ISSN (print): 0264-6021
ISSN (electronic): 1470-8728
URL: https://doi.org/10.1042/BCJ20220233
DOI: 10.1042/BCJ20220233
PubMed id: 37965929
