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Lookup NU author(s): Dr Ramzi LakhdarORCiD
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There is substantial evidence found in the literature that supports the fact that the presence of oxidative stress may play an important role in the pathophysiology of schizophrenia. The glutathione S-transferases (GSTs) forms one of the major detoxifying groups of enzymes responsible for eliminating products of oxidative stress. Interindividual differences observed in the metabolism of xenobiotics have been attributed to the genetic polymorphism of genes coding for enzymes involved in detoxification. Thus, in this study we investigated the association of glutathione S-transferase Mu-1 (GSTM1) and glutathione S-transferase theta-1 (GSTT1) gene deletion polymorphisms and schizophrenia in a Tunisian population. A case-control study including 138 schizophrenic patients and 123 healthy controls was enrolled. The GSTM1 and GSTT1 polymorphisms were analyzed by multiplex polymerase chain reaction (PCR). No association was found between the GSTM1 genotype and schizophrenia, whereas the prevalence of the GSTT1 active genotype was significantly higher in the schizophrenic patients (57.2%) than in the controls (45.5%) with (OR = 0.6, IC 0.37-0.99, p=0.039). Thus, we noted a significant association between schizophrenia and GSTT1 active genotype. Furthermore, the combination of the GSTM1 and GSTT1 null genotypes showed a non-significant trend to an increased risk of schizophrenia. The present finding indicated that GSTT1 seems to be a candidate gene for susceptibility to schizophrenia in at least Tunisian population. © 2012 Elsevier B.V.
Author(s): Raffa M, Lakhdar R, Ghachem M, Barhoumi S, Safar MT, Bel Hadj Jrad B, Haj Khelil A, Kerkeni A, Mechri A
Publication type: Article
Publication status: Published
Journal: Gene
Year: 2013
Volume: 512
Issue: 2
Pages: 282-285
Print publication date: 10/01/2013
Online publication date: 26/10/2012
ISSN (print): 0378-1119
ISSN (electronic): 1879-0038
Publisher: Elsevier
URL: https://doi.org/10.1016/j.gene.2012.10.031
DOI: 10.1016/j.gene.2012.10.031
PubMed id: 23107768
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