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Correlation of EPHX1, GSTP1, GSTM1, and GSTT1 genetic polymorphisms with antioxidative stress markers in chronic obstructive pulmonary disease

Lookup NU author(s): Dr Ramzi LakhdarORCiD

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Abstract

This study was undertaken to ascertain if a relationship existed between oxidative status and polymorphisms of microsomal epoxide hydrolase X1 (EPHX1), glutathione S-transferase P1 (GSTP1), GSTM1, and GSTT1 in chronic obstructive pulmonary disease (COPD). Erythrocyte glutathione peroxidase (GSH-px), glutathione reductase (GR), superoxide dismutase (SOD), catalase (CAT), and plasma GST activities and total antioxidant status (TAS) as antioxidative stress markers were determined and compared either with individual and combined genotypes of EPHX1 exon 3, GSTP1 exon 5, GSTM1, and GSTT1 polymorphisms in COPD patients and healthy controls from the central area of Tunisia. Statistical data processing revealed significantly lower GSH-px, GR, SOD, CAT, GST, and TAS values in COPD patients in comparison to the control group (P <.001). As for genotypes, there was a no significant association in each of the 6 parameters and individual genotypes (P >.05). A significant correlation between the studied parameters and combined null GSTM1/null GSTT1 (GSH-px: P <.001, GR: P =.026, CAT: P =.018, GST: P =.022, TAS: P =.046), His113His EPHX1/null GSTM1 (GSH-px: P =.001, GST: P =.0012, TAS: P =.013), His113His EPHX1/Val105Val GSTP1 (GSH-px: P =.048, CAT: P =.026, GST: P =.031), and null GSTM1/Val105Val GSTP1 (GSH-px: P =.011, GR: P =.0028, GST: P =.0054, TAS: P =.032) was found in patients. In conclusion, combined genetic polymorphisms of GSTM1, GSTT1, GSTP1, and EPHX1 may have favorable effects on redox balance in COPD patients. © 2011 Informa Healthcare USA, Inc.

Publication metadata

Author(s): Lakhdar R, Denden S, Mouhamed MH, Chalgoum A, Leban N, Knani J, Lefranc G, Miled A, Chibani JB, Khelil AH

Publication type: Article

Publication status: Published

Journal: Experimental Lung Research

Year: 2011

Volume: 37

Issue: 4

Pages: 195-204

Online publication date: 11/02/2011

ISSN (print): 0190-2148

ISSN (electronic): 1521-0499

Publisher: Taylor & Francis

URL: https://doi.org/10.3109/01902148.2010.535093

DOI: 10.3109/01902148.2010.535093

PubMed id: 21309732

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