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Lookup NU author(s): Dr Tobias Page
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© 2023 The Authors. BJUI Compass published by John Wiley & Sons Ltd on behalf of BJU International Company.Objective: To examine the safety and efficacy of prostatic urethral lift (PUL) in acute urinary retention (AUR) patients within a controlled (PULSAR) and real-world setting (Real-World Retrospective study). Materials and methods: PULSAR was a 12-month prospective study of PUL in AUR patients (n = 51) performed at six centres in the United Kingdom; enrolled BPH patients aged ≥50 years, with prostate volume of ≤100 cc. AUR was defined as being catheter dependent with at least one prior failed trial without catheter (TWOC) while on an alpha-blocker. RWR consisted of 3226 consecutive PUL patients across 22 international sites treated between July 2017 and March 2020; 469 of whom were in urinary retention (RWRr), that is, catheter-dependent at the time of their procedure. Symptom response, uroflow and catheter independence rates were compared between PULSAR and RWRr subjects. A logistical regression model was constructed to evaluate patient baseline and dynamic factors predicting success after the procedure. Results: Seventy-three percent of PULSAR subjects were catheter independent and free from surgical reintervention at 12 months post-PUL. Success was associated with higher voiding efficiency during the perioperative period. Slightly higher catheter-independent rates (80%) were seen in RWRr patients; variables that influenced success included age <70 years, lower baseline prostate-specific antigen (PSA), lower baseline post-void residual (PVR) and shorter pre-procedural catheter duration. Logistic regression of the combined PULSAR and RWRr retention groups revealed that procedural age <70 years and higher bladder voiding efficiency (BVE) were associated with success. Conclusions: Lower baseline PSA and PVR, younger age and shorter pre-procedure catheter durations drove successful outcomes in AUR patients undergoing PUL. Post-PUL voiding efficiencies may help ascertain long-term response to treatment.
Author(s): Rochester M, Doherty R, Page T, Barber N, Kavia R, Thiruchelvam N, Gange S, Mueller T, Eure G, Chin P, Kayes O
Publication type: Article
Publication status: Published
Journal: BJUI Compass
Year: 2024
Volume: 5
Issue: 1
Pages: 60-69
Print publication date: 01/01/2024
Online publication date: 08/09/2023
Acceptance date: 04/08/2023
ISSN (print): 1464-4096
ISSN (electronic): 1464-410X
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1002/bco2.280
DOI: 10.1002/bco2.280
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