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Roadmap to DILI research in Europe. A proposal from COST action ProEuroDILINet

Lookup NU author(s): Professor Ann DalyORCiD



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


© 2024 The AuthorsIn the current article the aims for a constructive way forward in Drug-Induced Liver Injury (DILI) are to highlight the most important priorities in research and clinical science, therefore supporting a more informed, focused, and better funded future for European DILI research. This Roadmap aims to identify key challenges, define a shared vision across all stakeholders for the opportunities to overcome these challenges and propose a high-quality research program to achieve progress on the prediction, prevention, diagnosis and management of this condition and impact on healthcare practice in the field of DILI. This will involve 1. Creation of a database encompassing optimised case report form for prospectively identified DILI cases with well-characterised controls with competing diagnoses, biological samples, and imaging data; 2. Establishing of preclinical models to improve the assessment and prediction of hepatotoxicity in humans to guide future drug safety testing; 3. Emphasis on implementation science and 4. Enhanced collaboration between drug-developers, clinicians and regulatory scientists. This proposed operational framework will advance DILI research and may bring together basic, applied, translational and clinical research in DILI.

Publication metadata

Author(s): Lucena MI, Villanueva-Paz M, Alvarez-Alvarez I, Aithal GP, Bjornsson ES, Cakan-Akdogan G, Cubero FJ, Esteves F, Falcon-Perez JM, Fromenty B, Garcia-Ruiz C, Grove JI, Konu O, Kranendonk M, Kullak-Ublick GA, Miranda JP, Remesal-Doblado A, Sancho-Bru P, Nelson L, Andrade RJ, Daly AK, Fernandez-Checa JC

Publication type: Article

Publication status: Published

Journal: Pharmacological Research

Year: 2024

Volume: 200

Print publication date: 06/01/2024

Online publication date: 28/12/2023

Acceptance date: 20/12/2023

Date deposited: 24/01/2024

ISSN (print): 1043-6618

ISSN (electronic): 1096-1186

Publisher: Academic Press


DOI: 10.1016/j.phrs.2023.107046

PubMed id: 38159783


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Funder referenceFunder name
Consejería de Salud de Andalucía (contract number: PEMP-0127–2020, Spain)
HORIZON-HLTH-2022-STAYHLTH-02, grant number 101095679
Instituto de Salud Carlos III (ISCIII) (contract numbers:PID2022–140169OB-C21; PI21/01248; PI19/00883)
Sara Borrell research contracts from ISCIII (CD21/00198 and CD20/00083)
the European Union
the Portuguese Fundação para a Ciência e a Tecnologia (FCT) UID/BIM/0009/2020