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Early Detection of Alzheimer's Disease with Blood Plasma Proteins Using Support Vector Machines

Lookup NU author(s): Professor Camille CarrollORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2013 IEEE. The successful development of amyloid-based biomarkers and tests for Alzheimer's disease (AD) represents an important milestone in AD diagnosis. However, two major limitations remain. Amyloid-based diagnostic biomarkers and tests provide limited information about the disease process and they are unable to identify individuals with the disease before significant amyloid-beta accumulation in the brain develops. The objective in this study is to develop a method to identify potential blood-based non-amyloid biomarkers for early AD detection. The use of blood is attractive because it is accessible and relatively inexpensive. Our method is mainly based on machine learning (ML) techniques (support vector machines in particular) because of their ability to create multivariable models by learning patterns from complex data. Using novel feature selection and evaluation modalities, we identified 5 novel panels of non-amyloid proteins with the potential to serve as biomarkers of early AD. In particular, we found that the combination of A2M, ApoE, BNP, Eot3, RAGE and SGOT may be a key biomarker profile of early disease. Disease detection models based on the identified panels achieved sensitivity (SN) > 80%, specificity (SP) > 70%, and area under receiver operating curve (AUC) of at least 0.80 at prodromal stage (with higher performance at later stages) of the disease. Existing ML models performed poorly in comparison at this stage of the disease, suggesting that the underlying protein panels may not be suitable for early disease detection. Our results demonstrate the feasibility of early detection of AD using non-amyloid based biomarkers.

Publication metadata

Author(s): Eke CS, Jammeh E, Li X, Carroll C, Pearson S, Ifeachor E

Publication type: Article

Publication status: Published

Journal: IEEE Journal of Biomedical and Health Informatics

Year: 2021

Volume: 25

Issue: 1

Pages: 218-226

Print publication date: 01/01/2021

Online publication date: 27/04/2020

Acceptance date: 26/03/2020

Date deposited: 31/01/2024

ISSN (print): 2168-2194

ISSN (electronic): 2168-2208

Publisher: IEEE


DOI: 10.1109/JBHI.2020.2984355

PubMed id: 32340968


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Funder referenceFunder name
European Union Horizon 2020
Marie-Sklodowska Curie Action Innovative Training Network