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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2023, Springer Nature Limited. The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.
Author(s): Towns C, Richer M, Jasaityte S, Stafford EJ, Joubert J, Antar T, Martinez-Carrasco A, Makarious MB, Casey B, Vitale D, Levine K, Leonard H, Pantazis CB, Screven LA, Hernandez DG, Wegel CE, Solle J, Nalls MA, Blauwendraat C, Singleton AB, Tan MMX, Iwaki H, Morris HR, Gatto EM, Kauffman M, Khachatryan S, Tavadyan Z, Shepherd CE, Hunter J, Kumar K, Ellis M, Renteria ME, Koks S, Zimprich A, Schumacher-Schuh AF, Rieder C, Awad PS, Tumas V, Camargos S, Fon EA, Monchi O, Fon T, Galleguillos BP, Miranda M, Bustamante ML, Olguin P, Chana P, Tang B, Shang H, Guo J, Chan P, Luo W, Arboleda G, Orozco J, del Rio MJ, Hernandez A, Salama M, Kamel WA, Zewde YZ, Brice A, Corvol J-C, Westenberger A, Illarionova A, Mollenhauer B, Klein C, Vollstedt E-J, Hopfner F, Hoglinger G, Madoev H, Trinh J, Junker J, Lohmann K, Lange LM, Sharma M, Groppa S, Gasser T, Fang Z-H, Akpalu A, Xiromerisiou G, Hadjigorgiou G, Dagklis I, Tarnanas I, Stefanis L, Stamelou M, Dadiotis E, Medina A, Chan GH-F, Ip N, Cheung NY-F, Chan P, Zhou X, Kishore A, Kp D, Pal P, Kukkle PL, Rajan R, Borgohain R, Salari M, Quattrone A, Valente EM, Parnetti L, Avenali M, Schirinzi T, Funayama M, Hattori N, Shiraishi T, Karimova A, Kaishibayeva G, Shambetova C, Kruger R, Tan AH, Ahmad-Annuar A, Norlinah MI, Murad NAA, Azmin S, Lim S-Y, Mohamed W, Tay YW, Martinez-Ramirez D, Rodriguez-Violante M, Reyes-Perez P, Tserensodnom B, Ojha R, Anderson TJ, Pitcher TL, Sanyaolu A, Okubadejo N, Ojo O, Aasly JO, Pihlstrom L, Tan M, Ur-Rehman S, Cornejo-Olivas M, Doquenia ML, Rosales R, Vinuela A, Iakovenko E, Mubarak BA, Umair M, Tan E-K, Foo JN, Amod F, Carr J, Bardien S, Jeon B, Kim YJ, Cubo E, Alvarez I, Hoenicka J, Beyer K, Perinan MT, Pastor P, El-Sadig S, Zweier C, Krack P, Lin C-H, Wu H-C, Kung P-J, Wu R-M, Wu Y, Amouri R, Sassi SB, Basak AN, Genc G, Cakmak OO, Ertan S, Noyce A, Schrag A, Schapira A, Carroll C, Bale C, Grosset D, Houlden H, Hardy J, Mok KY, Rizig M, Wood N, Williams N, Okunoye O, Lewis PA, Kaiyrzhanov R, Weil R, Love S, Stott S, Jasaitye S, Dey S, Obese V, Espay A, O'Grady A, Sobering AK, Siddiqi B, Fiske B, Jonas C, Cruchaga C, Comart C, Wegel C, Hall D, Hernandez D, Shiamim E, Riley E, Faghri F, Serrano GE, Chen H, Mata IF, Sarmiento IJK, Williamson J, Kim JJ, Jankovic J, Shulman J, Solle JC, Murphy K, Nuytemans K, Kieburtz K, Markopoulou K, Marek K, Levine KS, Chahine LM, Ibanez L, Screven L, Ruffrage L, Shulman L, Marsili L, Kuhl M, Dean M, Koretsky M, Puckelwartz MJ, Inca-Martinez M, Louie N, Mencacci NE, Albin R, Alcalay R, Walker R, Bandres-Ciga S, Chowdhury S, Dumanis S, Lubbe S, Xie T, Foroud T, Beach T, Sherer T, Song Y, Nguyen D, Nguyen T, Atadzhanov M
Publication type: Article
Publication status: Published
Journal: npj Parkinson's Disease
Year: 2023
Volume: 9
Online publication date: 12/09/2023
Acceptance date: 22/05/2023
Date deposited: 30/01/2024
ISSN (electronic): 2373-8057
Publisher: Springer Nature
DOI: 10.1038/s41531-023-00533-w
Data Access Statement: GP2 has partnered with the Accelerating Medicines Partnership - Parkinson’s Disease (https://amp-pd.org) to share data generated by GP2; in December 2021 the first GP2 genotyping data were released on the AMP-PD platform. As of 2023, the data consist of 14,902 samples (8190 PD cases), representing a broad range of diverse ancestries defined directly from the genotyping data from these cohorts. Genotyping and data QC is ongoing; there will be regular data releases as the project progresses. All contributing investigators have access to GP2 data - external researchers can also gain access by following instructions on the GP2 website (https://gp2.org/applying-for-gp2-data-access-on-the-amp-pd-platform/). There are two tiers of data access. Tier 1 consists of summary statistics and any researcher can gain access by completing an online application. Tier 2 access includes deidentified, individual level genetic data- researchers must sign a Data Usage Agreement co-signed by their institution
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