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Lookup NU author(s): Dr Ankita DasORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
Myocardial infarction (MI) can be tackled by implanting cardiac patches which provide mechanical support to the heart. However, most tissue-engineered scaffolds face difficulty in attenuating oxidative stress, maintaining mechanical stability, and regenerating damaged cardiomyocytes. Here, we fabricated elastic cryogels using polyurethane modified with antioxidant gallic acid in its backbone (PUGA) and further coated them with decellularized extracellular matrix (dECM) to improve adhesiveness, biocompatibility and hemocompatibility. The scaffold was functionalized with exosomes (EXO) isolated from adipose-derived stem cells having regenerative potential. PUGA-dECM + EXO was tested in a rat model with induced MI where echocardiography after 8 weeks of implantation showed significant recovery in treatment group. Histological analysis revealed a decrease in fibrosis after application of patch and promotion of angiogenesis with reduced oxidative stress was shown by immunostaining. Expression of cardiac tissue contractile function marker was also observed in treatment groups. Thus, the proposed biomaterial has a promising application to be utilized as a patch for cardiac regeneration. More detailed studies with larger animal species are needed for using these observations for specific applications.
Author(s): Das A, Nikhil A, Shiekh PA, Yadav B, Jagavelu K, Kumar A
Publication type: Article
Publication status: Published
Journal: Bioactive Materials
Year: 2024
Volume: 33
Pages: 324-340
Print publication date: 01/03/2024
Online publication date: 24/11/2023
Acceptance date: 16/11/2023
Date deposited: 12/02/2024
ISSN (print): 2097-1192
ISSN (electronic): 2452-199X
Publisher: KeAi Communications Co., Ltd
URL: https://doi.org/10.1016/j.bioactmat.2023.11.009
DOI: 10.1016/j.bioactmat.2023.11.009
Data Access Statement: All data are available in the main text or the supplementary material.
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