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Lookup NU author(s): Dr Ute JungwirthORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2022 The Authors. Experimental Dermatology published by John Wiley & Sons Ltd.Skin cancers are by far the most frequently diagnosed human cancers. The closely related transcriptional co-regulator proteins YAP and TAZ (WWTR1) have emerged as important drivers of tumour initiation, progression and metastasis in melanoma and non-melanoma skin cancers. YAP/TAZ serve as an essential signalling hub by integrating signals from multiple upstream pathways. In this review, we summarize the roles of YAP/TAZ in skin physiology and tumorigenesis and discuss recent efforts of therapeutic interventions that target YAP/TAZ in in both preclinical and clinical settings, as well as their prospects for use as skin cancer treatments.
Author(s): Howard A, Bojko J, Flynn B, Bowen S, Jungwirth U, Walko G
Publication type: Review
Publication status: Published
Journal: Experimental Dermatology
Year: 2022
Volume: 31
Issue: 10
Pages: 1477-1499
Print publication date: 01/10/2022
Online publication date: 01/08/2022
Acceptance date: 25/07/2022
ISSN (print): 0906-6705
ISSN (electronic): 1600-0625
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1111/exd.14655
DOI: 10.1111/exd.14655
PubMed id: 35913427
