ePrints

A Multicentre Prospective Evaluation of Health-Related Quality of Life and of Patient Related Outcomes in Pancreatic and Peripancreatic Cancer: PROMCAN study.

Lookup NU author(s): Dr Kate SwainstonORCiD, Professor Linda Sharp, Professor Catherine Exley, Professor Sanjay PandanaboyanaORCiD

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

© 2024 International Hepato-Pancreato-Biliary Association Inc.Background: The temporal evolution of HRQoL and the importance of other PROs to patients, following resection for pancreatic and peripancreatic malignancy remains unexplored. Methods: Patients undergoing pancreatic resection between 2021 and 2022 were enrolled from 2 UK HPB centres. Patients completed the EORTC QLQ-C30, QLQ-PAN26 tools and rated 56 PROs preoperatively (T1), at discharge (T2), 6-weeks (T3), 3-months (T4) and 6-months (T5) postoperatively. ANOVA followed by post-hoc analysis was used to examine patterns in HRQoL through time. Multivariable ANOVA was used to identify impact of clinical factors on HRQoL. Results: 63 patients were recruited [median age, 72 (IQR 41–85); 39/63 male]. Physical functioning declined from 70.4 (26.2) at T1 to 53.5 (20.9) at T2 (p = 0.016). Global QoL score increased significantly from 41.0 (23.0) at T2 to 60.0 (26.1) at T5 (p = 0.007), as did role functioning [21.1 (27.9) at T2 to 59.4 (32.8) at T5, p < 0.001]. Chemotherapy status and the postoperative complications did not significantly change HRQoL. General QoL and health were the only PROs rated as ‘very important’ (scores 7–9) by more than 80 % of participants at five time-points. Conclusion: Recuperation of HRQoL measures is seen at 6-months postoperative and was not affected by chemotherapy or postoperative complications. Notably, PROs important to patients varied over time.

Publication metadata

Author(s): Joseph N, Robertson F, Lucocq J, Pande R, Powell-Brett S, Swainston K, Sharp L, Exley C, Roberts K, Pandanaboyana S

Publication type: Article

Publication status: Published

Journal: HPB

Year: 2024

Volume: 26

Issue: 5

Pages: 648-655

Print publication date: 01/05/2024

Online publication date: 01/02/2024

Acceptance date: 26/01/2024

ISSN (print): 1365-182X

ISSN (electronic): 1477-2574

Publisher: Elsevier

URL: https://doi.org/10.1016/j.hpb.2024.01.016

DOI: 10.1016/j.hpb.2024.01.016.

Altmetrics

Share