Toggle Main Menu Toggle Search

Open Access padlockePrints

Plasma Myeloperoxidase as a Potential Biomarker of Patient Response to Anti-Dementia Treatment in Alzheimer's Disease

Lookup NU author(s): Anna Stevenson, Leolie Telford-Cooke, Dr Craig Parker, Dr Carmen Martin-RuizORCiD, Professor Raj KalariaORCiD, Dr Elizabeta Mukaetova-Ladinska


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


© 2022 - IOS Press. All rights reserved. Background: Myeloperoxidase (MPO), a neutrophil-derived pro-inflammatory protein, co-localizes with amyloid-β (Aβ) plaques in Alzheimer's disease (AD). Anti-dementia treatment may facilitate efflux of Aβ and associated plaque proteins from the brain to the peripheral circulation, therefore providing potential biomarkers for the monitoring of donor response to drug treatment. Objective: We investigated the diagnostic utility of MPO as a biomarker of AD, and how anti-dementia treatment alters plasma MPO concentration. Methods: Thirty-two AD patients were recruited, and plasma collected pre-drug administration (baseline), and 1- and 6-months post-treatment. All patients received cholinesterase inhibitors (ChEIs). At baseline and 6 months, patients underwent neuropsychological assessment. Forty-nine elderly healthy individuals with normal cognitive status served as controls. Plasma MPO concentration was measured by ELISA. Results: AD drug naïve patients had similar plasma MPO concentration to their control counterparts (p > 0.05). Baseline MPO levels positively correlated with Neuropsychiatric Inventory score (r = 0.5080; p = 0.011) and carer distress (r = 0.5022; p = 0.012). Following 1-month ChEI treatment, 84.4% of AD patients exhibited increased plasma MPO levels (p < 0.001), which decreased at 6 months (p < 0.001). MPO concentration at 1 month was greatest in AD patients whose memory deteriorated during the study period (p = 0.028), and for AD patients with deterioration in Cornell assessment score (p = 0.044). Conclusion: Whereas baseline MPO levels did not differentiate between healthy and AD populations, baseline MPO positively correlated with initial Neuropsychiatric Inventory evaluation. Post-treatment, transient MPO upregulation in ChEI-treated patients may reflect worse therapeutic outcome. Further studies are required to assess the potential of plasma MPO as an AD therapeutic biomarker.

Publication metadata

Author(s): Wright JR, Deen QFE, Stevenson A, Telford-Cooke LL, Parker C, Martin-Ruiz C, Steinert JR, Kalaria RN, Mukaetova-Ladinska EB

Publication type: Article

Publication status: Published

Journal: Journal of Alzheimer's Disease

Year: 2022

Volume: 89

Issue: 4

Pages: 1483-1492

Print publication date: 11/10/2022

Online publication date: 01/09/2022

Acceptance date: 31/07/2022

ISSN (print): 1387-2877

ISSN (electronic): 1875-8908

Publisher: IOS Press BV


DOI: 10.3233/JAD-220642

PubMed id: 36057826


Altmetrics provided by Altmetric