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Tubulin and Tubulin Posttranslational Modifications in Alzheimer’s Disease and Vascular Dementia

Lookup NU author(s): Professor Raj KalariaORCiD, Dr Elizabeta Mukaetova-Ladinska



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Copyright © 2021 Santiago-Mujika, Luthi-Carter, Giorgini, Kalaria and Mukaetova-Ladinska. Alzheimer’s disease (AD) and vascular dementia (VaD) are the two most common forms of dementia in older people. Although these two dementia types differ in their etiology, they share many pathophysiological and morphological features, including neuronal loss, which is associated with the microtubule (MT) destabilization. Stabilization of MTs is achieved in different ways: through interactions with MT binding proteins (MTBP) or by posttranslational modifications (PTMs) of tubulin. Polyglutamylation and tyrosination are two foremost PTMs that regulate the interaction between MTs and MTBPs, and play, therefore, a role in neurodegeneration. In this review, we summarize key information on tubulin PTMs in relation to AD and VaD and address the importance of studying further the tubulin code to reveal sites of potential intervention in development of novel and effective dementia therapy.

Publication metadata

Author(s): Santiago-Mujika E, Luthi-Carter R, Giorgini F, Kalaria RN, Mukaetova-Ladinska EB

Publication type: Review

Publication status: Published

Journal: Frontiers in Aging Neuroscience

Year: 2021

Volume: 13

Online publication date: 29/10/2021

Acceptance date: 04/10/2021

ISSN (electronic): 1663-4365

Publisher: Frontiers Media S.A.


DOI: 10.3389/fnagi.2021.730107