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Accelerated Corneal Crosslinking to Arrest Progression of Corneal Ectasia: A Prospective Multicenter Study

Lookup NU author(s): Professor Francisco FigueiredoORCiD

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Abstract

© 2024 Lippincott Williams and Wilkins. All rights reserved.Objectives: To report the results of epithelium-off accelerated corneal collagen crosslinking (accelerated corneal crosslinking [ACXL]) in patients with progressive keratoconus. Methods: This prospective, nonrandomized, noncomparative, interventional, multicenter clinical study included all patients who underwent ACXL, either continuous (c-ACXL; 9 mW/cm2, 109, 5.4 J/cm2) or pulsed (p-ACXL; 299ON/199OFF, 30 mW/cm2, 4.59, 5.4 J/cm2) between January 2014 and May 2017. Best-corrected visual acuity, sphere, cylinder, spherical equivalent, and topographical keratometry data were collected preoperatively and at 1, 3, 6, 12, 18, and 24 months postoperatively. Results: Ninety-six eyes of 78 patients were included. The mean age was 20.864.4 years (14-33) for c-ACXL and 26.767.7 years (12-37) for p-ACXL. The mean best-corrected visual acuity was 0.460.4 for c-ACXL and 0.0160.1 for p-ACXL preoperatively, and 0.360.3 (P¼0.0014) and 20.0160.1 (P¼0.1554), respectively, at the last followup. The subjective sphere and spherical equivalent did not show statistically significant differences between the time points (P.0.05). The subjective cylinder showed significant differences (P¼0.0013 for c-ACXL; P¼0.0358 for p-ACXL). Keratometric values (Ksteep, Kflat, and SimK) remained stable, with no statistically significant differences (P.0.05). No major complications were noted. Conclusions: Both c-ACXL and p-ACXL are equally safe and effective ACXL protocols in stabilizing the progression of keratoconus and can be considered alternatives to the conventional Dresden protocol.

Publication metadata

Author(s): Salvador-Culla B, Afsara A, Roper N, Mulroy J, Galankova L, Duncan H, Tabibian D, Lamarca-Mateu J, Figueiredo FC

Publication type: Article

Publication status: Published

Journal: Eye and Contact Lens

Year: 2024

Volume: 50

Issue: 3

Pages: 126-131

Online publication date: 01/03/2024

Acceptance date: 02/04/2018

ISSN (print): 1542-2321

ISSN (electronic): 1542-233X

Publisher: Lippincott Williams and Wilkins

URL: https://doi.org/10.1097/ICL.0000000000001065

DOI: 10.1097/ICL.0000000000001065

PubMed id: 38345049

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