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Lookup NU author(s): Abdullah Malik, Dr Sam Tingle, Dr Balaji Mahendran, Professor Derek Manas, Professor Colin Wilson, Steven White
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
© 2024 The AuthorsThe time to arrest donors after circulatory death is unpredictable and can vary. This leads to variable periods of warm ischemic damage prior to pancreas transplantation. There is little evidence supporting procurement team stand-down times based on donor time to death (TTD). We examined what impact TTD had on pancreas graft outcomes following donors after circulatory death (DCD) simultaneous pancreas-kidney transplantation. Data were extracted from the UK transplant registry from 2014 to 2022. Predictors of graft loss were evaluated using a Cox proportional hazards model. Adjusted restricted cubic spline models were generated to further delineate the relationship between TTD and outcome. Three-hundred-and-seventy-five DCD simultaneous kidney-pancreas transplant recipients were included. Increasing TTD was not associated with graft survival (adjusted hazard ratio HR 0.98, 95% confidence interval 0.68-1.41, P = .901). Increasing asystolic time worsened graft survival (adjusted hazard ratio 2.51, 95% confidence interval 1.16-5.43, P = .020). Restricted cubic spline modeling revealed a nonlinear relationship between asystolic time and graft survival and no relationship between TTD and graft survival. We found no evidence that TTD impacts pancreas graft survival after DCD simultaneous pancreas-kidney transplantation; however, increasing asystolic time was a significant predictor of graft loss. Procurement teams should attempt to minimize asystolic time to optimize pancreas graft survival rather than focus on the duration of TTD.
Author(s): Malik AK, Tingle SJ, Chung N, Owen R, Mahendran B, Counter C, Sinha S, Muthasamy A, Sutherland A, Casey J, Drage M, van Dellen D, Callaghan CJ, Elker D, Manas DM, Pettigrew GJ, Wilson CH, White SA, NHSBT Pancreas Advisory Group
Publication type: Article
Publication status: Published
Journal: American Journal of Transplantation
Year: 2024
Volume: 24
Issue: 7
Pages: 1247-1256
Print publication date: 01/07/2024
Online publication date: 14/02/2024
Acceptance date: 07/02/2024
Date deposited: 18/03/2024
ISSN (print): 1600-6135
ISSN (electronic): 1600-6143
Publisher: Elsevier B.V.
URL: https://doi.org/10.1016/j.ajt.2024.02.008
DOI: 10.1016/j.ajt.2024.02.008
Data Access Statement: The data used in this manuscript is managed by the United Kingdom Transplant Registry through NHS Blood and Transplant (NHSBT). The authors are not able to provide the raw data, however this may be requested from NHS BT through written request.
PubMed id: 38360185
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