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Lookup NU author(s): Abdullah Malik, David Talbot, Steven White, David Rix, Professor Derek Manas, Aimen Amer, Professor Colin Wilson
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INTRODUCTION: Iliac lymphadenectomy is performed to provide anastomotic access during the vascular implantation procedure in renal transplantation. Iliac lymph nodes (LNs) are often enlarged, but there are no standardised guidelines for the management of incidentally enlarged LNs during transplantation. We aimed to evaluate histological findings of LNs sent for examination at our unit. METHODS: Patients were evaluated in two distinct date cycles. In the first cycle, lymphadenectomy and histological assessment were performed at the discretion of the transplanting surgeon. In the second cycle, all incidentally enlarged LNs were sent for histological assessment, regardless of size. RESULTS: In the first cycle (n = 76), 11 patients (14.47%) had incidentally enlarged iliac LNs on lymphadenectomy and histology showed only reactive changes. In the second cycle (n = 165), eight patients (4.85%) had incidentally enlarged LNs on lymphadenectomy. One patient was found to have mature B cell chronic lymphocytic leukaemia. The patient was referred to haematology and a "watch and wait" approach was taken, with the patient still alive at last follow-up (511 days post-transplantation). DISCUSSION: There are currently no published guidelines on the management of incidentally enlarged iliac LNs during transplantation. Current literature suggests that clinically significant lymphadenopathy needs to be investigated in all patients. Based on our centre's experience of a 5.26% (1 in 19) positive pathological LN sampling, we recommend that all incidental LNs with suspicious features and/or that are greater than 10mm in diameter should be considered for histological, microbiological and molecular assessment as appropriate.
Author(s): Ho NX, Malik AK, Moulding S, Farrow F, Talbot D, White S, Rix D, Sen G, Manas D, Amer A, Figuereido R, Wilson CH
Publication type: Article
Publication status: Published
Journal: Annals of the Royal College of Surgeons of England
Year: 2024
Volume: 106
Issue: 3
Pages: 245-248
Print publication date: 01/03/2024
Online publication date: 25/07/2023
Acceptance date: 24/05/2023
ISSN (electronic): 1478-7083
Publisher: Royal College of Surgeons of England
URL: https://doi.org/10.1308/rcsann.2023.0043
DOI: 10.1308/rcsann.2023.0043
PubMed id: 37489513
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