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Genetic alterations in lymphoblastic leukaemia / lymphoma – a practical guide to WHO HAEM5

Lookup NU author(s): Dr Lisa Russell

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2024 the author(s), published by De Gruyter.We present a practical guide for analyzing the genetic aspects of lymphoblastic leukaemia/lymphoma according to the 5th edition of the World Health Organization (WHO) classification of haematolymphoid neoplasms (WHO-HAEM5) issued in 2024. The WHO-HAEM5 acknowledges the increasing importance of genetics in the diagnosis of lymphoid neoplasia. Classification is based on the established genetic subtypes according to cell lineage, with precursor cell neoplasms followed by mature malignancies. This guide describes those genetic abnormalities in acute precursor B- and T-cell neoplasms required for risk stratification, and for treatment, providing diagnostic algorithms under the headings of ‘essential’ and ‘desirable’ diagnostic criteria.

Publication metadata

Author(s): Steinemann D, Dawidowska M, Russell LJ, Harrison CJ, Gohring G

Publication type: Article

Publication status: Published

Journal: Medizinische Genetik

Year: 2024

Volume: 36

Issue: 1

Pages: 39-45

Print publication date: 01/04/2024

Online publication date: 06/03/2024

Acceptance date: 02/04/2023

Date deposited: 25/03/2024

ISSN (print): 0936-5931

ISSN (electronic): 1863-5490

Publisher: Walter de Gruyter GmbH

URL: https://doi.org/10.1515/medgen-2024-2007

DOI: 10.1515/medgen-2024-2007

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