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Lookup NU author(s): Dr Gill NormanORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Introduction: Lung transplantation is the gold standard treatment for end-stage lung disease for a small group of patients meeting strict acceptance criteria after optimal medical management has failed. Physical frailty is prevalent in lung transplant candidates and has been linked to worse outcomes both on the waiting list and postoperatively. Exercise has been proven to be beneficial in optimising exercise capacity and quality of life in lung transplant candidates but its impact on physical frailty is unknown. This review aims to assess the effectiveness of exercise interventions in modifying physical frailty for adults awaiting lung transplantation. Methods and Analysis: This protocol was prospectively registered on the PROSPERO database. We will search four databases plus trials registries to identify primary studies of adult candidates for lung transplantation undertaking exercise interventions and assessing outcomes pertaining to physical frailty. Studies must include at least ten participants. Article screening will be performed by two researchers independently at each stage. Extraction will be performed by one reviewer and checked by a second. The risk of bias in studies will be assessed by two independent reviewers using tools appropriate for the research design of each study; where appropriate we will use Cochrane risk of bias 2 or ROBINS-I. At each stage of the review process discrepancies will be resolved through consensus or consultation with a third reviewer. Meta-analyses of frailty outcomes, will be performed if possible and appropriate as will pre-specified subgroup and sensitivity analyses. Where we are unable to perform meta-analysis we will conduct narrative synthesis following SWiM guidance. The review will be reported using the PRISMA Checklist.Ethics and Dissemination: No ethical issues are predicted due to the nature of this study. Dissemination will occur via conference abstracts, professional networks, peer reviewed journals and patient support groups. Registration Details: PROSPERO registration number CRD42022363730.
Author(s): McGarrigle L, Norman G, Hurst H, Todd C
Publication type: Article
Publication status: Published
Journal: BMJ Open
Year: 2024
Volume: 14
Issue: 4
Online publication date: 03/04/2024
Acceptance date: 30/01/2024
Date deposited: 25/03/2024
ISSN (electronic): 2044-6055
Publisher: BMJ Group
URL: https://doi.org/10.1136/bmjopen-2023-078561
DOI: 10.1136/bmjopen-2023-078561
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