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Lookup NU author(s): Sam SeeryORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Background Colposcopy is an important tool in diagnosing cervical cancer, and the International Federation of Cervical Pathology and Colposcopy (IFCPC) issued the latest version of the guidelines in 2011. This study aims to systematically assess the accuracy of colposcopy in predicting low-grade squamous intraepithelial lesions or worse (LSIL+) / high-grade squamous intraepithelial lesions or worse (HSIL+) under the 2011 IFCPC terminology. Methods We performed a systematic review and meta-analysis, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched for studies about the performance of colposcopy in diagnosing cervical intraepithelial neoplasia under the new IFCPC colposcopy terminology from PubMed, Embase, Web of Science and the Cochrane database. Data were independently extracted by two authors and an overall diagnostic performance index was calculated under two colposcopic thresholds. Results In total, fifteen articles with 22,764 participants in compliance with the criteria were included in meta-analysis. When colposcopy was used to detect LSIL+, the combined sensitivity and specifcity were 0.92 (95% CI 0.88–0.95) and 0.51 (0.43–0.59), respectively. When colposcopy was used to detect HSIL+, the combined sensitivity and specifcity were 0.68 (0.58–0.76) and 0.93 (0.88–0.96), respectively. Conclusion In accordance with the 2011 IFCPC terminology, the accuracy of colposcopy has improved in terms of both sensitivity and specifcity. Colposcopy is now more sensitive with LSIL+ taken as the cut-of value and is more specifc to HSIL+. These fndings suggest we are avoiding under- or overdiagnosis both of which impact on patients’ well-being.
Author(s): Qin D, Bai A, Xue P, Seery S, Wang J, Mendez M, Li Q, Jiang Y, Qiao Y
Publication type: Article
Publication status: Published
Journal: BMC cancer
Year: 2023
Volume: 23
Issue: 1
Print publication date: 23/02/2023
Online publication date: 23/02/2023
Acceptance date: 14/02/2023
Date deposited: 26/03/2024
ISSN (electronic): 1471-2407
Publisher: BMC
URL: https://doi.org/10.1186/s12885-023-10648-1
DOI: 10.1186/s12885-023-10648-1
Data Access Statement: The data generated in the present study may be requested from the corresponding authors.
PubMed id: 36823557
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