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Lookup NU author(s): Kimberley Noble, Dr Oisín KavanaghORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The AuthorsIn this study, we present the first meta-analysis of human urine reported in the literature, drawing data from a total of 35 articles with a combined participant count of 14,021. Through this analysis, we have developed an artificial urine (AU) composition that can be adjusted within typical physiological parameters for in vitro applications. Our findings demonstrate the utility of this AU in determining the solubility of nitrofurantoin, particularly in the context of crystalluria. Notably, we observe that in saline, nitrofurantoin solubility, within the framework of its urinary pharmacokinetics, suggests a risk of crystalluria. However, in AU, this risk is mitigated due to complexation with urea. More broadly, we anticipate that our developed formulation will serve as a foundation for translational studies across biomedical and pharmaceutical sciences.
Author(s): Noble KA, Chan HKY, Kavanagh ON
Publication type: Article
Publication status: Published
Journal: European Journal of Pharmaceutics and Biopharmaceutics
Year: 2024
Volume: 198
Print publication date: 01/05/2024
Online publication date: 16/03/2024
Acceptance date: 13/03/2024
Date deposited: 03/04/2024
ISSN (print): 0939-6411
ISSN (electronic): 1873-3441
Publisher: Elsevier B.V.
URL: https://doi.org/10.1016/j.ejpb.2024.114264
DOI: 10.1016/j.ejpb.2024.114264
Data Access Statement: Data will be made available on request.
PubMed id: 38492868
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