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Lookup NU author(s): Caelinn James, Dr Marco Trevisan-HerrazORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The AuthorsTopologically associated domains (TADs) are interaction subnetworks of chromosomal regions in 3D genomes. TAD boundaries frequently coincide with genome breaks while boundary deletion is under negative selection, suggesting that TADs may facilitate genome rearrangements and evolution. We show that genes co-localize by evolutionary age in humans and mice, resulting in TADs having different proportions of younger and older genes. We observe a major transition in the age co-localization patterns between the genes born during vertebrate whole-genome duplications (WGDs) or before and those born afterward. We also find that genes recently duplicated in primates and rodents are more frequently essential when they are located in old-enriched TADs and interact with genes that last duplicated during the WGD. Therefore, the evolutionary relevance of recent genes may increase when located in TADs with established regulatory networks. Our data suggest that TADs could play a role in organizing ancestral functions and evolutionary novelty.
Author(s): James C, Trevisan-Herraz M, Juan D, Rico D
Publication type: Article
Publication status: Published
Journal: Cell Reports
Year: 2024
Volume: 43
Issue: 4
Print publication date: 23/04/2024
Online publication date: 21/03/2024
Acceptance date: 16/02/2024
Date deposited: 04/04/2024
ISSN (electronic): 2211-1247
Publisher: Elsevier B.V.
URL: https://doi.org/10.1016/j.celrep.2024.113895
DOI: 10.1016/j.celrep.2024.113895
Data Access Statement: This paper analyses existing, publicly available data. These accession numbers for the datasets are listed in the key resources table. All original code has been deposited at https://github.com/ricolab/TAD_Evolution and https://doi.org/10.5281/zenodo.10067329 and is publicly available as of the date of publication. DOIs are listed in the key resources table. Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.
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