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Tumor necrosis factor-alpha in psoriasis and psoriatic arthritis: a clinical, genetic, and histopathologic perspective

Lookup NU author(s): Dr David Kane

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Abstract

The successful introduction of anti-tumor necrosis factor (TNF) therapies in psoriasis and psoriatic arthritis has sharpened considerable interest in this chronic and frequently disabling disease. Unlike the situation in rheumatoid arthritis, where anti-TNF therapies were introduced after years of painstaking research which confirmed a key proinflammatory role for TNF, the evidence for TNF having a key role in psoriatic arthritis has lagged behind. In this paper, the emerging immunohistochemical, genetic, and clinical literature relating to TNF's role in skin and joint manifestations of this disease is reviewed and areas for future research are suggested.

Publication metadata

Author(s): Kane D, FitzGerald O

Publication type: Article

Publication status: Published

Journal: Current Rheumatology Reports

Year: 2004

Volume: 6

Issue: 4

Pages: 292-298

Print publication date: 01/08/2004

ISSN (print): 1523-3774

ISSN (electronic): 1534-6307

Publisher: Current Medicine Group LLC

URL: http://dx.doi.org/10.1007/s11926-004-0041-0

DOI: 10.1007/s11926-004-0041-0

Notes: 1523-3774 Journal Article Review Review, Tutorial

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