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Lookup NU author(s): Dr Elizabeth Veal
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H2O2 signals trigger adaptive responses affecting cell division, differentiation, migration and survival. These signals are transduced by selective oxidation of cysteines on specific target proteins, with redox-sensitive cysteines now identified in many proteins, including both kinases and phosphatases. Assessing the contribution of these oxidation events to cell signaling, presents several challenges, including understanding how and when the selective oxidation of specific proteins takes place in vivo. In recent years, a combination of biochemical, structural, genetic and computational approaches in fungi, plants and animals have revealed different ways in which thiol peroxidases(peroxiredoxins) are bypassed or utilized in relaying these signals. Together these mechanisms provide a conceptual framework for selectively oxidizing signaling proteins that will further advance understanding of how redox modifications contribute to health and disease.
Author(s): Veal EA, Kritsiligkou P
Publication type: Article
Publication status: In Press
Journal: Current Opinion in Chemical Biology
Year: 2024
Acceptance date: 09/06/2024
ISSN (print): 1367-5931
ISSN (electronic): 1879-0402
Publisher: Elsevier Ltd.