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FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

Lookup NU author(s): Professor Andrew FisherORCiD, Dr Bill ScottORCiD

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Author(s): Brevini T, Maes M, Webb GJ, John BV, Fuchs CD, Buescher G, Wang L, Griffiths C, Brown ML, Scott III WE, Pereyra-Gerber P, Gelson WTH, Brown S, Dillon S, Muraro D, Sharp J, Neary M, Box H, Tatham L, Stewart J, Curley P, Pertinez H, Forrest S, Mlcochova P, Varankar SS, Darvish-Damavandi M, Mulcahy VL, Kuc RE, Williams TL, Heslop JA, Rossetti D, Tysoe OC, Galanakis V, Vila-Gonzalez M, Crozier TWM, Bargehr J, Sinha S, Upponi SS, Fear C, Swift L, Saeb-Parsy K, Davies SE, Wester A, Hagstrom H, Melum E, Clements D, Humphreys P, Herriott J, Kijak E, Cox H, Bramwell C, Valentijn A, Illingworth CJR, Consortium UK-PBC, Dahman B, Bastaich DR, Ferreira RD, Marjot T, Barnes E, Moon AM, Barritt IV AS, Gupta RK, Baker S, Davenport AP, Corbett G, Gorgoulis VG, Buczacki SJA, Lee JH, Matheson NJ, Trauner M, Fisher AJ, Gibbs P, Butler AJ, Watson CJE, Mells GF, Dougan G, Owen A, Lohse AW, Vallier L, Sampaziotis F

Publication type: Article

Publication status: Published

Journal: Nature

Year: 2023

Volume: 615

Pages: 134-142

Online publication date: 05/12/2022

Acceptance date: 23/11/2022

Date deposited: 20/05/2024

ISSN (print): 0028-0836

ISSN (electronic): 1476-4687

Publisher: Springer

URL: https://doi.org/10.1038/s41586-022-05594-0

DOI: 10.1038/s41586-022-05594-0

Data Access Statement: scRNA-seq data are available on ArrayExpress under accession number E-MTAB-8495. Source data are provided with this paper.

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Funding

Funder referenceFunder name
Addenbrooke’s Charitable Trust (grant ref. to 900239)
an NIHR Clinical Lectureship
BHF TG/18/4/33770
EASL Juan Rodès PhD fellowship
EPSRC (EP/R024804/1)
Medical Research Council (MC_UU_12014)
MR/L001489/1Medical Research Council (MRC)
MRC (MR/P008801/1)
MRC Clinical Academic Research Partnership (CARP) award
NHSBT (grant ref. WPA15-02)
NIHR AMR Research Capital Funding Scheme (NIHR200640)
the Academy of Medical Sciences Starter Grant for Clinical Lecturers
the European Association for the Study of the Liver (EASL)
the Wellcome Trust (222489/Z/21/Z)
UKRI Future Leaders fellowship
The Addenbrooke’s Charitable Trust and the Rosetrees Trust
the American Association for the Study of Liver Disease (AASLD)
the European Reference Network for Hepatological Diseases (ERN RARE LIVER)
the Evelyn trust
the National Institute for Health Research (NIHR) Rare Diseases– Translational Research Collaboration (RD-TRC)
the National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU)
the Wellcome Trust
the Wellcome Trust (203151/Z/16/Z, 203151/A/16/Z)
the Wellcome Trust and Medical Research Council (MRC) of the Wellcome–Medical Research Council Cambridge Stem Cell Institute
Wellcome Trust 203814/Z/16/A
UK Research and Innovation (BB/W010801/1)
Unitaid (2020-38-LONGEVITY)
Wellcome Trust Clinical Research Training Fellowship (102176/B/13/Z)

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