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Lookup NU author(s): Fiona Malcomson, Professor John Mathers
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The Author(s)Background and aims: Research into the relationship between an Energy-adjusted Diet-Inflammatory Index (E-DII) and a wider health-related biomarkers profile is limited. Much of the existing evidence centers on traditional metabolic biomarkers in populations with chronic diseases, with scarce data on healthy individuals. Thus, this study aims to investigate the association between an E-DII score and 30 biomarkers spanning metabolic health, endocrine, bone health, liver function, cardiovascular, and renal functions, in healthy individuals. Methods and results: 66,978 healthy UK Biobank participants, the overall mean age was 55.3 (7.9) years were included in this cross-sectional study. E-DII scores, based on 18 food parameters, were categorised as anti-inflammatory (E-DII < -1), neutral (−1 to 1), and pro-inflammatory (>1). Regression analyses, adjusted for confounding factors, were conducted to investigate the association of 30 biomarkers with E-DII. Compared to those with an anti-inflammatory diet, individuals with a pro-inflammatory diet had increased levels of 16 biomarkers, including six cardiometabolic, five liver, and four renal markers. The concentration difference ranged from 0.27 SD for creatinine to 0.03 SD for total cholesterol. Conversely, those on a pro-inflammatory diet had decreased concentrations in six biomarkers, including two for endocrine and cardiometabolic. The association range varied from −0.04 for IGF-1 to −0.23 for SHBG. Conclusion: This study highlighted that a pro-inflammatory diet was associated with an adverse profile of biomarkers linked to cardiometabolic health, endocrine, liver function, and renal health.
Author(s): Carrasco-Marin F, Zhao L, Hebert JR, Wirth MD, Petermann-Rocha F, Phillips N, Malcomson FC, Mathers JC, Ferguson LD, Ho F, Pell J, Celis-Morales C, Molina-Recio G, Molina-Luque R
Publication type: Article
Publication status: Published
Journal: Nutrition, Metabolism and Cardiovascular Diseases
Year: 2024
Pages: epub ahead of print
Online publication date: 14/03/2024
Acceptance date: 07/03/2024
Date deposited: 08/05/2024
ISSN (print): 0939-4753
ISSN (electronic): 1590-3729
Publisher: Elsevier B.V.
URL: https://doi.org/10.1016/j.numecd.2024.03.010
DOI: 10.1016/j.numecd.2024.03.010
PubMed id: 38664123
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