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Lookup NU author(s): Dr David Ledingham, Professor Mark BakerORCiD, Professor Nicola PaveseORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
Local field potentials (LFPs) are signals generated primarily by the result of the synchronous discharge of postsynapticpotentials. Detection of LFPs from intracranial electrodes sited within the basal ganglia has led to therecognition that there are specific features of the LFP that could serve as neurophysiological biomarkers ofdifferent disease states. For example, in Parkinson’s disease peaks in the beta frequency range of the powerspectrum are known to correlate with the degree of bradykinesia and rigidity, whereas low frequency, alphathetapeaks are increasingly considered a biomarker of dystonic activity. The introduction of newer deepbrain stimulation (DBS) devices capable of simultaneous stimulation and LFP detection creates opportunities toinvestigate new strategies for treating patients with dystonia. This review aims to summarise the LFP findingsseen in patients with dystonia undergoing DBS with a particular focus on the potential implications for futureclinical practice and the development of adaptive DBS systems.
Author(s): Ledingham D, Baker M, Pavese N
Publication type: Review
Publication status: Published
Journal: Deep Brain Stimulation
Year: 2024
Volume: 5
Pages: 4-19
Print publication date: 01/08/2024
Online publication date: 21/03/2024
Acceptance date: 19/03/2024
ISSN (print): 1935-861X
ISSN (electronic): 1876-4754
URL: https://doi.org/10.1016/j.jdbs.2024.03.003
DOI: 10.1016/j.jdbs.2024.03.003
