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Lookup NU author(s): Jenny Kartsaki, Dr Gerrit Hilgen, Professor Evelyne SernagorORCiD
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© 2024 Massachusetts Institute of Technology. We consider a model of basic inner retinal connectivity where bipolar and amacrine cells interconnect and both cell types project onto ganglion cells, modulating their response output to the brain visual areas. We derive an analytical formula for the spatiotemporal response of retinal ganglion cells to stimuli, taking into account the effects of amacrine cells inhibition. This analysis reveals two important functional parameters of the network: (1) the intensity of the interactions between bipolar and amacrine cells and (2) the characteristic timescale of these responses. Both parameters have a profound combined impact on the spatiotemporal features of retinal ganglion cells' responses to light. The validity of the model is confirmed by faithfully reproducing pharmacogenetic experimental results obtained by stimulating excitatory DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) expressed on ganglion cells and amacrine cells' subclasses, thereby modifying the inner retinal network activity to visual stimuli in a complex, entangled manner. Our mathematical model allows us to explore and decipher these complex effects in a manner that would not be feasible experimentally and provides novel insights in retinal dynamics.
Author(s): Kartsaki E, Hilgen G, Sernagor E, Cessac B
Publication type: Article
Publication status: Published
Journal: Neural Computation
Year: 2024
Volume: 36
Issue: 6
Pages: 1041-1083
Online publication date: 10/05/2024
Acceptance date: 02/01/2024
ISSN (print): 0899-7667
ISSN (electronic): 1530-888X
Publisher: MIT Press
URL: https://doi.org/10.1162/neco_a_01663
DOI: 10.1162/neco_a_01663
PubMed id: 38669693
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