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Lookup NU author(s): Alaa Alyahya, Dr Sarah Charman, Dr Nduka Okwose, Dr Amy Fuller, Professor Christopher EggettORCiD, Peter LukeORCiD, Dr Guy MacGowanORCiD, Professor Djordje JakovljevicORCiD
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© Copyright 2024 The Author(s). Background: A limited number of studies have investigated the effects of lifestyle interventions in hypertrophic cardiomyopathy (HCM). This study evaluated the effect of a novel lifestyle intervention incorporating physical activity (PA) and dietary nitrate supplementation on heart rate variability (HRV) and haemodynamic measures in HCM. Methods: Twenty-eight individuals with HCM were randomised into either the intervention or control group. Frequency-domain HRV measures including low frequency power (LF), high frequency power (HF) and LF/HF were recorded at rest using bioimpedance. Non-invasive haemodynamic variables were recorded at rest using bioreactance. Participants in the intervention group consumed 6 mmol of nitrate daily (concentrated beetroot juice) and were instructed to increase and maintain daily PA by ≥ 2000 steps/day above baseline for 16 weeks. Control group participants retained their usual lifestyle and monitored daily step counts. Results: There was a significant increase in post-intervention HF power (7.54 ± 2.14 vs 8.78 ± 1.60 ms2, P <.01) and LF power (6.89 ± 2.33 vs 8.17 ± 1.55, P <.01) in the intervention but not in the control group. Resting mean arterial blood pressure (MABP) in the intervention group significantly reduced at follow-up (108 ± 6 vs 102 ± 7 mmHg, P <.01). Conclusions: A novel lifestyle intervention including PA and dietary nitrate supplementation enhanced parasympathetic activity and resting MABP in HCM.
Author(s): Alyahya AI, Charman SJ, Okwose NC, Fuller AS, Eggett C, Luke P, Bailey K, MacGowan GA, Jakovljevic DG
Publication type: Article
Publication status: Published
Journal: American Journal of Lifestyle Medicine
Year: 2024
Pages: ePub ahead of Print
Online publication date: 16/05/2024
Acceptance date: 02/04/2018
ISSN (print): 1559-8276
ISSN (electronic): 1559-8284
Publisher: SAGE Publications Inc.
URL: https://doi.org/10.1177/15598276241253187
DOI: 10.1177/15598276241253187
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