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Lookup NU author(s): Dr Gurdeep SagooORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Background: Despite reported increases in referral numbers, a large proportion of those with prediabetes still decline participation in the NHS England Diabetes Prevention Programme (NDPP). The aim of this study was to explore whether investment in interventions to improve uptake of the programme has the potential to be cost-effective. Methods: An early cost-utility analysis was conducted using a Markov model parameterized based on secondary data sources. We explored different uptake scenarios and the impact that this had on the maximum allowable intervention price based on cost-effectiveness at the UK NICE willingness to pay threshold of £20,000 (US$ 25,913). Value of information analyses were conducted to explore the potential value of further research to resolve uncertainty at each uptake level. Results: As uptake levels increase, the maximum allowable intervention price and overall expected value of removing decision uncertainty increases. For 5 percentage and 50 percentage points increase in uptake levels, the maximum allowable intervention price is £41.86 (US$ 54.23) and £418.59 (US$ 542.34) per person, and the overall expected value of removing decision uncertainty are £361,818,839 (US$ 468,786,625) and £1,468,712,316 (US$ 1,902,921,063) respectively. Conclusion: There is headroom for investment in interventions that improve uptake to the NDPP, thereby allowing the programme itself to be delivered in a manner that remains cost-effective.
Author(s): Frempong SN, Shinkins B, Howdon D, Messenger M, Neal RD, Sagoo GS
Publication type: Article
Publication status: Published
Journal: Expert Review of Pharmacoeconomics and Outcomes Research
Year: 2022
Volume: 22
Issue: 3
Pages: 417-427
Online publication date: 12/03/2021
Acceptance date: 23/02/2021
Date deposited: 14/06/2024
ISSN (print): 1473-7167
ISSN (electronic): 1744-8379
Publisher: Taylor and Francis Ltd
URL: https://doi.org/10.1080/14737167.2021.1895755
DOI: 10.1080/14737167.2021.1895755
PubMed id: 33682555
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