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Lookup NU author(s): Emeritus Professor David Brooks
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The Author(s)Diets high in sucrose and fat are becoming more prevalent the world over, accompanied by a raised prevalence of cardiovascular diseases, cancers, diabetes, obesity, and metabolic syndrome. Clinical studies link unhealthy diets with the development of mental health disorders, particularly depression. Here, we investigate the effects of 12 days of sucrose consumption administered as 2 L of 25% sucrose solution daily for 12 days in Göttingen minipigs on the function of brain receptors involved in reward and motivation, regulating feeding, and pre- and post-synaptic mechanisms. Through quantitative autoradiography of cryostat sections containing limbic brain regions, we investigated the effects of sucrose restricted to a 1-h period each morning, on the specific binding of [3H]raclopride on dopamine D2/3 receptors, [3H]UCB-J at synaptic vesicle glycoprotein 2A (SV2A), [3H]MPEPγ at metabotropic glutamate receptor subtype 5 (mGluR5) and [3H]SR141716A at the cannabinoid receptor 1 (CB1). Compared to control diet animals, the sucrose group showed significantly lower [3H]UCB-J and [3H]MPEPγ binding in the prefrontal cortex. The sucrose-consuming minipigs showed higher hippocampal CB1 binding, but unaltered dopamine D2/3 binding compared to the control group. We found that the sucrose diet reduced the synaptic density marker while increasing CB1 binding in limbic brain structures, which may subserve maladaptive changes in appetite regulation and feeding. Further studies of the effects of diets and lifestyle habits on brain neuroreceptor and synaptic density markers are warranted.
Author(s): Baerentzen SL, Thomsen MB, Alstrup AK, Wegener G, Brooks DJ, Winterdahl M, Landau AM
Publication type: Article
Publication status: Published
Journal: Neuropharmacology
Year: 2024
Volume: 256
Print publication date: 15/09/2024
Online publication date: 27/05/2024
Acceptance date: 25/05/2024
Date deposited: 18/06/2024
ISSN (print): 0028-3908
ISSN (electronic): 1873-7064
Publisher: Elsevier Ltd
URL: https://doi.org/10.1016/j.neuropharm.2024.110018
DOI: 10.1016/j.neuropharm.2024.110018
PubMed id: 38810925
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